VSB may refer to

• Vestigial sideband
• 8-VSB, digital vestigial sideband modulation used by ATSC.
• Agreement of Friendship, Cooperation, and Mutual Assistance (from its Finland-Swedish acronym)
• VSB-TV, an NBC affiliate in Bermuda
• Very Small Business
• School District 39 Vancouver (commonly known as the Vancouver School Board, or VSB)

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