VMS may stand for:

• OpenVMS and FreeVMS, a computer server operating system
• Variable-message sign, an electronic traffic sign often used on highways
• Vendor Management System, a process or system for managing vendors (e.g., temporary staff)
• Visual Memory System, a storage device for the Sega Dreamcast console better known as a Visual Memory Unit (VMU)
• Voice Mail System
• Volcanogenic massive sulfide ore deposits, a type of metal sulfide ore deposit
• Voynich manuscript, a mysterious illustrated book with incomprehensible contents
• Vessel monitoring system, a near real-time, usually satellite-based, positional tracking system for fishing vessels
• Vallivue Middle School, a middle school in the Vallivue School District.
• Vandenberg Middle School, a middle school in the Lompoc Unified School District
• Video Monitoring Services, a news and advertisements monitoring company.
• Vietnam Mobile Telecom Services Company, one of the largest mobile phone operators in Vietnam

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