The abbreviation SPS can stand for:
- Educational and scholarly institutions
- St. Patrick's School, Asansol, an old school in Asansol, India
- St. Paul's School (Concord, New Hampshire), a boarding school in the United States
- St Paul's School (London), a day and boarding school in the United Kingdom
- School of Practical Science, of the University of Toronto in Canada
- Sigma Pi Sigma, a fraternity in in the United States
- Social and Political Sciences, of the University of Cambridge in the United Kingdom
- Society for Pentecostal Studies, an association of biblical scholars
- Society of Physics Students, an international professional association
- Software Preservation Society, a society dedicated to preserving obsolete software
- Political parties and government agencies
- Technology
- Other uses
- Samples Per Second, the frequency of samples taken from a continuous signal to make a discrete signal
- San Pedro Sula, a city in Honduras
- Sanitary and Phytosanitary Agreement, an international treaty of the World Trade Organization
- Single Payment Scheme, farm subsidy in the EU
- Small Penis Syndrome, a psychological condition
- Spark Plasma Sintering, a sintering technique
- Spokane, Portland and Seattle Railway, a defunct railroad in the United States
- Station Police Sergeant, a defunct British police rank
- Statistic Process Control, a method of monitoring a process through the use of control charts
- Stiff person syndrome, a rare neurologic disorder
- Sussex Piscatorial Society, a fishing club in the United Kingdom
- Wichita Falls Municipal Airport (IATA airport code)
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