São Francisco do Sul is a municipality in the Brazilian state of Santa Catarina.

It covers an area of 493 km² (190 miles²) and had an estimated population of 37,725 in 2005.^{citation needed}

São Francisco do Sul is the third-oldest post-Columbian city in Brazil. It is situated on the northern end of the island of São Francisco do Sul at the entrance to the Bay of Babitonga.

v • d • e Norte Catarinense mesoregion of Santa Catarina , Brazil mesoregions of Santa Catarina: Grande Florianópolis • Norte Catarinense • Oeste Catarinense • Serrana • Sul Catarinense • Vale do Itajaí Canoinhas Bela Vista do Toldo • Canoinhas • Irineópolis • Itaiópolis • Mafra • Major Vieira • Monte Castelo • Papanduva • Porto União • Santa Terezinha • Timbó Grande • Três Barras Joinville Araquari • Balneário Barra do Sul • Corupá • Garuva • Guaramirim • Itapoá • Jaraguá do Sul • Joinville • Massaranduba • São Francisco do Sul • Schroeder São Bento do Sul Campo Alegre • Rio Negrinho • São Bento do Sul

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Coordinates: 26°14′34″S, 48°38′16″W