NME may refer to:

• New Musical Express is a magazine in the UK which has been published weekly since March 1952.
• A term in drug design describing a new molecular entity.
• New Medium Enterprises, that unifies the HD DVD and Blu-ray formats.
• Nightmare Enterprises from Kirby: Right Back at Ya!, referred to as NME in the intro.
• Necrolytic migratory erythema
• National Medical Enterprises, a former name of Tenet Healthcare Corporation.
• National Military Establishment, the former name of the Department of Defense.
• Nissan Motorsport Europe, a British based motorsport arm of Nissan, sometimes referred to as NME

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