Notable people with the name Lewis Powell include:

• Lewis Franklin Powell, Jr. was an Associate Justice of the Supreme Court of the United States from 1972 until 1987.
• Lewis Powell (assassin), alias "Lewis Payne", was one of the conspirators hanged for taking part in the plot to assassinate President Abraham Lincoln. He was the assassin that stabbed Secretary of State William H. Seward on the night when his conspirator John Wilkes Booth shot Lincoln.
• Lewis Powell, semi-professional football player for Weston-super-Mare and ex-Bristol Rovers player.

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