Leopold II is a human name, and may refer to:
- Leopold II, Grand Duke of Tuscany (1797-1870), Archduke of Austria
- Leopold II, Holy Roman Emperor (1747-1792), Grand Duke of Tuscany
- Leopold II, Margrave of Austria (1050-1095), fifth Margrave of Austria
- Leopold II, Prince of Anhalt-Dessau (1700-1751), Prussian general
- Leopold II, Prince of Lippe (1796-1851), eldest child of Leopold I and Princess Pauline
- Leopold II of Belgium (1835-1909), King of the Belgians
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