Last Chance Creek may refer to:

• The creek in which the Four Georgians discovered gold, in what is now Helena, Montana
  • Last Chance Gulch, the main street of Helena, beneath which flows what remains of this creek
• A creek in Plumas County, California
• A creek in southern Utah
• A creek in Yukon Territory, Canada
• A creek in Alaska

There are probably many other creeks with this name, as it was common for prospectors to decide that a particular location was their "last chance" to find gold before having to return for supplies.

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