ISD can mean:

• Internet Standard Document, a standard issued by the IETF
• Independent School District
• Imperial Star Destroyer from Star Wars
• Indiana School for the Deaf
• Information Services Department of the Hong Kong Government
• International School of Düsseldorf
• Instructional Systems Design
• Internal Security Department of the Republic of Singapore
• International Subscriber Dialling
• Inhibited sexual desire, a sexual dysfunction also known as "frigidity."
• Interactive Science Discovery activity, a tiebreak system used in the National Science Bowl.
• In-school detention
• Interaural spectral difference
• ISD GmbH, a SME located in Ludwigshafen am Rhein, Germany

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