HCI can mean:

Computing

• Home Computer Initiative, a United Kingdom government programme designed to increase the use of computers in the home
• Host controller interface, a storage interface (at register level) controller for both internal and external ports. (e.g. USB, SATA, Bluetooth...etc.)
• Human-computer interaction, the study of how people interact with computers
• Human-computer interaction (security), the study of how people interact with computers concerning information security
• Human-computer interface, the technical term for a user interface

Schools

• Harbord Collegiate Institute, a school in Toronto, Canada
• Humberside Collegiate Institute, a school in Toronto, Canada
• Hwa Chong Institution, a school located in Singapore

Other

• Handgun Control Incorporated, the former name of the Brady Campaign to Prevent Gun Violence
• HCI is a common typographical error for hydrogen chloride or hydrochloric acid

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