Fred, Frederic, or Frederick Smith may refer to:
- Fred Smith (politician), a North Carolina legislator and attorney
- Fred Smith (bassist), bassist for the 1970s proto-punk band Television
- Fred L. Smith, president and founder of the Competitive Enterprise Institute
- Fred "Sonic" Smith, guitarist with the MC5
- Fred Smith (cricketer), cricketer who played three Test matches for South Africa in the late 19th century
- Fred Smith (1890s pitcher) (1863–1941), former Major League Baseball player
- Fred Smith (1900s pitcher) (1878–1964), former MLB pitcher
- Fred Vincent Smith (1886–1961), former Major League Baseball player
- The stage name of Australian folk singer/songwriter and comedian Iain Campbell Smith
- Frederic H. Smith, Jr., a United States Air Force general
- Frederick Smith (entomologist)
- Frederick Augustus Smith
- Frederick Cleveland Smith (1884–1956), U. S. Representative from Ohio
- Frederick E. Smith (author) (born 1922), British author
- F. E. Smith, 1st Earl of Birkenhead
- Frederick Smith, 2nd Earl of Birkenhead
- Frederick Smith, 3rd Earl of Birkenhead
- Frederick M. Smith
- Frederick W. Smith (born 1944), founder of Federal Express
- Frederick Smith, 2nd Viscount Hambleden (1868–1928), British MP
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