FRB may mean:

• Federal Reserve Bank of the United States of America
• Fractional-reserve banking
• Front Running Bastard - as used by Hash House Harriers
• Flatredball
• Federal Reserve Bank of China
• Free Radio Berkeley
• IATA code for Forbes Airport, New South Wales, Australia
• FKBP12-Rapamycin Binding
• Code for Fairbourne railway station, Wales, United Kingdom
• Rubidium fluoride (FRb)
• Fast Rescue Boat
• Federal Retirement Benefits
• New York Stock Exchange stock code for "BlackRock Floating Rate Income Strategies Fund II, Inc."
• FlatRedBall FlatRedBall Game Engine

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