Ed Sprague can refer to:

• Ed Sprague (pitcher) (b. 1945), a pitcher in major league baseball from 1968-1976
• Ed Sprague (third baseman) (b. 1967), a third baseman in major league baseball from 1991-2001

This disambiguation page lists articles associated with the same personal name. If an article link led you here, you may wish to change the link to point directly to the intended article.