E3, E.III, E03, E-3 or E³ can refer to:

In sports and games:

• E3 Prijs Vlaanderen (English: E3 Prize Flanders), a professional cycling race held in Belgium
• E3, one of the European long-distance paths

In military:

• E-3 Sentry, an AWACS aircraft based on the Boeing 707
• Fokker E.III, a 1915 Dutch fighter aircraft
• HMS E3, an E-class submarine of the British Royal Navy
• Pfalz E.III, a German aircraft powered by the Oberursel U.I engine
• Siemens-Schuckert E.III, a German aircraft powered by the Oberursel U.I engine
• E-3 (rank), a paygrade in the United States Military

In organizations:

• E3 Media and Business Summit (formerly known as the Electronic Entertainment Expo), a yearly computer and video game expo and conference
• E3, Germany, United Kingdom and France, the three nations with the largest populations and economies within the European Union

In places:

• London E3, the postal code for Bow in London

In science and technology:

• E3 binding protein, a protein
• E-3 process, an obsolete development process associated with photographic transparency film
• e3 (text editor), a text editor
• Honda E3, a 1991 Honda E series ASIMO predecessor robot
• Olympus E-3, a digital SLR camera
• E3, a clade of the human Y-chromosome DNA haplogroup E
• E3, a communications channel defined in the E-carrier standard
• E³.series, electrical CAD software
• Dihydrolipoamide dehydrogenase, the third element of the pyruvate dehydrogenase complex

In transportation:

• E3 National Highway, a National Highways of Pakistan
• E3 Series Shinkansen, a Japanese high-speed train
• EMD E3, a diesel locomotive
• European route E03, a European route
• LB&SCR E3 Class, a 1894 British class of steam locomotives
• London Buses route E3, a bus route in London
• Mazda E engine#E3
• PRR E3, an American PRR 4-4-2 steam locomotive

and also :

• Domodedovo Airlines IATA airline designator

In other:

• E-3 visa, a non-immigrant visa allowing Australian citizens to live and work in the United States
• E03 : Other hypothyroidism ICD-10 code

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