Charles Jackson may refer to:
- Charles Jackson (jurist) (1775-1855), American judge
- Charles Jackson (Rhode Island) (1797-1876), Governor of Rhode Island
- Charles Douglas Jackson, an advisor of Dwight Eisenhower.
- Charles Loring Jackson (1847-1935), American chemist
- Charles R. Jackson, an author best known for his 1944 novel, The Lost Weekend.
- Charles Samuel Jackson, a newspaper publisher.
- Charles Thomas Jackson, (1805-1880), American physician, chemist, author, inventor, surveyor, and geologist
- Charles Jackson (football player), American football player
- Charlie Jackson (software), Software entrepreneur
- Charlie Jackson (American football), American football coach
- Charlie Jackson (MLB outfielder) (1894-1968), a MLB outfielder
- Charlie Jackson (NASCAR), NASCAR driver
- Papa Charlie Jackson, (c.1890-1938), American blues singer
- Rev. Charlie Jackson, African-American gospel guitarist and singer
- Chuck Jackson (b. 1937), a R&B singer
- Chuck Jackson (MLB third baseman) (b. 1963), an MLB third baseman
- Chuck Jackson (blues singer), singer with the Canadian group Downchild Blues Band
- Charlie Jackson (rummy player) notable cheater,hangs with Tony D. Hamilton
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