• Charlie Pierce (Charles P. Pierce) (born 1953), American sportswriter.
• Charles Pierce (1926–1999), American female impersonator.
• Charles B. Pierce (born 1938), American film director.
• Charles H. Pierce, Philippine-American War Medal of Honor recipient
• Charles Wilson Pierce (1823-1907), U.S. Representative from Alabama.
• Charles Pierce Davey (Chuck Davey) (1925-2002), American-born welterweight boxer and boxing commissioner for the state of Michigan.
• Edward C. Pierce (Edward Charles Pierce) (1930-2002), politician and physician from the U.S. state of Michigan.
• Justin Pierce (Justin Charles Pierce) (1975–2000), English-American actor and professional skateboarder.
• Ricky Pierce (Ricky Charles Pierce) (born 1959), retired American National Basketball Association player.

See also

• Charles Peirce (Charles Sanders Peirce) (1839-1914), American logician, mathematician, scientist, philosopher, whose family name is often mis-spelled "Pierce".

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