Charles Cavendish may refer to:
- Lord Charles Cavendish, (circa 1700-1783), English politician and scientist
- Lord William Charles Augustus Cavendish-Bentinck, (1780-1826), great-great-grandfather of Queen Elizabeth II
- Charles Compton Cavendish, 1st Baron Chesham, (1793-1863), English Liberal politician
- Charles Cavendish Fulke Greville, (1794-1865), English political figure and diarist of historical events
- Reverend Charles William Frederick Cavendish-Bentinck, (1817-1865), Church of England clergyman
- Lord Frederick Charles Cavendish, (1836-1882), English Liberal politician who was assassinated in Ireland
- Sir Charles Cavendish Boyle, (1849-1916), British colonial administrator
- Charles Compton William Cavendish, 3rd Baron Chesham, (1850-1907), English Conservative politician
- William John Arthur Charles James Cavendish-Bentinck, 6th Duke of Portland, (1857-1943), owner of celebrated thoroughbred horses
- John Charles Compton Cavendish, 5th Baron Chesham, (1916-1989), English Conservative politician
- Nicholas Charles Cavendish, 6th Baron Chesham, (born 1941), English Conservative politician
- Charles Cavendish (b. 1974), (born 1974), English personality, eldest son of Nicholas Cavendish, 6th Baron Chesham
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