CDO may refer to:

• Collateralized debt obligation, a structured finance product
• Central dense overcast, in a tropical storm
• Cysteine dioxygenase, an enzyme
• Connected Data Objects, a free implementation of a Distributed Shared Model on top of the Eclipse Modeling Framework (EMF)
• Collaboration Data Objects, a Microsoft application programming interface for data access
• Continuous Duty Overnight, a regional airline crew scheduling term
• The ISO-639 code for Min Dong
• Chief Data Officer, an information systems title
• Chief Dental Officer (Canada), a Canadian official who advises the public and federal government on oral-health
• Chief Dental Officer (United Kingdom) (or CDO) for England, the British Government’s most senior advisor for dentistry
• Cagayan de Oro, a city in the Philippines
• Cañada del Oro, a primary watershed channel in the valley of Tucson, Arizona, USA
• Canyon del Oro High School, a public school in Oro Valley, Arizona, USA

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