Robert MacKenzie or Robert Mackenzie may refer to:

• Robert Mackenzie (Queensland politician) (1811-1873), premier of Queensland, Australia, August 1867 to November 1868.
• Robert Mackenzie Johnston (1844–1918), Scottish-Australian statistician and man of science.
• R. Tait McKenzie (1867-1938), Canadian-born American surgeon and sculptor
• Robert W. Mackenzie (born 1928), Canadian politician, cabinet minister
• Robert C. MacKenzie (1948–1995), American professional soldier noteworthy for service in the Rhodesian SAS

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